Atalanta are buzzing after a 5-1 demolition of Everton and host a Benevento side still looking for their first Serie A point.
After recording stirring victories in the last round, both Bologna and Sampdoria will be aiming to build momentum at the Stadio Dall’Ara.
Inter have the opportunity to temporarily go top of the table, but visit a Cagliari side finding their form under Diego Lopez.
Newly-promoted SPAL are unbeaten in three and visit a Chievo side without a win in four rounds, but there are four players suspended.
With both sides earning crucial victories in the last round, Genoa will look to end their terrible home record when they host Roma.
Juventus need to answer their critics and get back on track against struggling Crotone.
There are some blasts from the past with Milan and Torino who have so far failed to live up to expectations.
Sassuolo will be eager to heap more misery on a floundering Hellas Verona in this Saturday evening relegation dogfight.