It’s rarely dull with these teams and this should be no exception, as Atalanta and Torino go head-to-head for European ambitions.
Cagliari are starting to struggle and they host a Sampdoria side fired up and angry after a last-gasp defeat to Inter.
Milan are still seeking some consistency after two consecutive Serie A draws, but Empoli wonder where their early promise has gone.
This is already starting to look like not only a relegation dogfight, but also a crucial turning point for two Coaches in trouble.
Mauro Icardi’s penalty and a Danilo D’Ambrosio give-and-go sealed Inter’s victory over Fiorentina, despite a Federico Chiesa deflected strike.
Juventus have a 100 per cent record after five rounds and Pippo Inzaghi’s Bologna are fresh from an upset by beating Roma 2-0.
Carlo Ancelotti is set to continue his tactical experiments for Napoli while facing up to some familiar faces at revitalised Parma.
Roma are in a deep crisis and face the first of two local derbies, as Frosinone hope to cause an upset before Lazio step in.
The two surprise outfits of the season so far go head-to-head at the Stadio Mazza, as SPAL and Sassuolo provide an advert for Serie A.
Lazio appear to have found their rhythm after a shaky start and visit an Udinese side also beginning to get into gear under new boss Julio Velazquez.