Juventus must regain their confidence after a disastrous Champions League defeat to Atletico Madrid, but visit Sinisa Mihajlovic’s rejuvenated Bologna.
This is a Lazio regional derby and Roma are confident they can secure a third consecutive Serie A victory against Frosinone in penultimate place.
Milan have really found their form and confidence, so expect full points against an Empoli side who struggle on their travels.
After losing their last three matches, Sampdoria face a must-win game against a highly motivated Cagliari team.
Torino and Atalanta go head-to-head in a fight for Europa League places, as there are only three points separating them going into the weekend.