There is plenty of motivation at the Stadio Dall’Ara, as Bologna are just two points clear of the drop zone, Sampdoria want Europe and Fabio Quagliarella as Capocannoniere.
Time is running out for Frosinone and they visit a Cagliari side on the verge of securing Serie A safety, so this result could prove decisive for both.
It is likely to be an entertaining game between relegation battlers Empoli and SPAL, both fresh from giant-killing exploits.
These sides are fighting for very different goals, as Genoa aren’t yet safe from the drop and Torino are in the race for Europe.
Luciano Spalletti, Radja Nainggolan, Claudio Ranieri and Nicolò Zaniolo face their former clubs in a showdown for Champions League places.
Juventus need only a point to secure their eighth consecutive Scudetto, but will be in no mood to celebrate against old rivals Fiorentina.
Lazio won their rescheduled midweek round and are still only three points off fourth place, but Chievo’s relegation is confirmed.
Milan retained fourth place with a hard-fought and controversial win over Lazio and now travel to injury-hit Parma.
While Sassuolo have probably done enough to secure their Serie A status, Udinese remain only three points clear of the relegation zone.