This game could go a long way in showing how the rest of the season will pan out for Atalanta and Lazio.
Napoli aim to recover from their heartbreaking Champions League exit when they visit a Cagliari side still unbeaten on home turf.
The last few weeks have seen a complete transformation in fortunes for Fiorentina and Empoli, setting up an unpredictable Tuscan Derby.
Sassuolo have gone badly off the boil lately and visit a Frosinone side desperate for points to survive in Serie A.
Inter look to bounce back from their midweek Champions League elimination when they host Udinese on Saturday.
Roma will be desperate to put their Serie A campaign back on track when they host Cesare Prandelli’s struggling Genoa on Sunday.
Only one point separates these sides going into the weekend, as Sampdoria and Parma have unlikely European ambitions.
Leonardo Semplici’s SPAL host strugglers Chievo Verona at the Stadio Paolo Mazza this weekend, where a win could take them into mid-table.
It’s Derby Della Mole time in Turin as a much-improved Torino welcome their illustrious neighbours Juventus on Saturday night.