A free header from Lorenzo Tonelli proved decisive, as Sampdoria put Atalanta back into crisis with victory in Bergamo.
Lucas Castro inspired Cagliari with two fantastic crosses for the head of Joao Pedro and Leonardo Pavoletti to beat Bologna 2-0.
Roma earned a fourth consecutive victory in all competition with Steven Nzonzi and Edin Dzeko, but Empoli hit the woodwork and missed a penalty.
Krzysztof Piatek was on target again, but Parma completed a remarkable comeback to conquer Genoa for the first time since 1994.
Ciro Immobile ended his Fiorentina curse with the first goal against the Viola, as Lazio squeezed a tense 1-0 victory.
Gonzalo Higuain struck twice and Suso completed a hat-trick of assists for Jack Bonaventura, but 39-year-old Sergio Pellissier got a consolation for Chievo.
Adam Ounas celebrated his first Serie A goal and Lorenzo Insigne curled a stunner into the top corner as Napoli saw off Sassuolo.
Mauro Icardi’s brace – with a deflection on the first – allowed Inter to scrape a 2-1 victory, but SPAL will rue a missed penalty.
Torino will be expected to get the points on Friday night as they host struggling Frosinone, but must improve in front of goal.
Juventus made it a Perfect 10 to start the season, as Rodrigo Bentancur and Cristiano Ronaldo conquered Udinese, with Simone Scuffet keeping the scoreline down.