Atalanta will look to put an embarrassing Champions League defeat firmly behind them as they take on struggling Fiorentina.
Bologna and Roma head into Sunday’s match as two of the four remaining undefeated sides in Serie A, and both squads are riding high after some big wins.
Cagliari left it late to claim their first Serie A home win of the season on Friday, beating Genoa 3-1 with a three-minute salvo.
Juventus fell off the top of the Serie A table after almost two years and host revitalised Hellas Verona after a midweek Atletico Madrid draw.
Frustration is growing at Lazio after almost identical defeats to SPAL and Cluj, while Parma are also struggling this season.
Napoli are buzzing after beating Champions League holders Liverpool, while Lecce also caused a stir with their shock victory at Torino.
The Derby della Madonnina of the season has Inter looking to continue their perfect Serie A start against their city rivals, whose season is yet to take off.
Eusebio Di Francesco is already facing threats of the sack after three straight defeats, as Sampdoria host a Torino side fresh from their own huge setback.
SPAL got off the mark with a comeback to beat Lazio, but Sassuolo’s all-attack approach is proving risky.
This already feels like a relegation dogfight, with Udinese and Brescia both coming off two consecutive defeats.