Mario Balotelli is suspended following his temper tantrum, so won’t face his former club, as Milan try to build on their improving form against Brescia.
Fiorentina have really turned a corner under Beppe Iachini and are fresh from three consecutive wins in all competition, but Genoa are rock bottom.
Inter have dropped four points off Juventus after back-to-back draws and need to stop the slide against Radja Nainggolan’s Cagliari in crisis.
Maurizio Sarri returns to the Stadio San Paolo for the first time as an opponent, on the Juventus bench no less, as Napoli try to avoid a record losing streak.
The Parma injury crisis is back in full swing as they host Udinese, with both teams coming off unlucky defeats.
It’s going to be a fascinating edition of the Derby della Capitale, as Lazio are on a run of 11 consecutive Serie A victories and Roma can close the gap from third place.
It’s touch and go for veteran striker Fabio Quagliarella as Claudio Ranieri prepares Sampdoria to fight Sassuolo in a vital game between direct rivals in Serie A.
This is a local derby, as Ferrara and Bologna are bordering towns, and SPAL are fired up after their shock victory over Atalanta.
Torino and Atalanta are both coming off deeply disappointing and surprising defeats, but the Granata are also missing key players.
Verona continue to sit comfortably mid-table, but Lecce received a boost after taking points off Scudetto challengers Inter.