Benevento and Cagliari are desperate for points in the race for survival and their meeting could determine the last team to be relegated to Serie B.
There is plenty of motivation on both sides, as Fiorentina are hovering above the drop zone and Lazio can still break into the Champions League battle.
Genoa are close to securing survival, while Sassuolo can still qualify for Europe.
Inter are Champions of Italy with four rounds to spare, but that doesn’t mean they’ll take it easy against Sampdoria.
Atalanta continue the battle for top four in Serie A against Parma, who have officially been relegated with four games remaining.
Roma aim to extend their perfect record against Crotone on Sunday.
Napoli have a shortage of defenders as they visit a Spezia side desperate to escape the relegation zone and who already beat them once this season.
Both Udinese and Bologna are virtually safe from the threat of relegation, needing only a point to be sure.
Hellas Verona are in poor shape ahead of the match against Torino, who are desperate to build on their win against Parma last time.