The Emilia-Romagna Derby is always a fiery affair, with both Bologna and Parma eager to make up for rough starts to the season.
Manuel Lazzari and Ciro Immobile made the most of their chances to give Lazio an opening victory in Sardinia, but Cagliari were too wasteful.
Milan continued their perfect start to the season, breaking down defensive Crotone with Franck Kessie and Brahim Diaz, but Ante Rebic suffered a nasty injury.
It was the return of Pazza Inter, as they scored two goals in two minutes to beat Fiorentina 4-3 after trailing 3-2 in a spectacular seven-goal San Siro thriller.
Napoli racked up a tennis score by humiliating Genoa 6-0, with Chucky Lozano bagging a brace, but Lorenzo Insigne went off injured.
Cristiano Ronaldo and Jordan Veretout scored a brace each, as Juventus twice pegged back Roma for a 2-2 draw, even after Adrien Rabiot saw red.
Benevento completed an extraordinary comeback from 2-0 down to beat Sampdoria 3-2 at Marassi, with Luca Caldirola’s brace and Gaetano Letizia.
Sassuolo gave Spezia a rude awakening to life in Serie A with a clinical 4-1 away victory in Sunday's early kick-off.
Atalanta showed no signs of slowing down as they opened the new Serie A season with a 4-2 win at Torino on Saturday.
Andrea Favilli’s first ever Serie A goal proved the difference to maintain Verona’s perfect start to the season, as Udinese clipped the crossbar twice.