Roma bring in Edoardo Bove with Paulo Dybala and Romelu Lukaku for the Europa League quarter-final, as Rafael Leao and Olivier Giroud try to turn it around.
It kicks off at the Stadio Olimpico at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens from this game, Fiorentina-Viktoria Plzen and Atalanta-Liverpool on the LIVEBLOG.
The first leg ended 1-0 for the Giallorossi at San Siro thanks to a Gianluca Mancini header, just days after he also decided the Derby della Capitale against Lazio.
Sunday’s Serie A game against Udinese was suspended at the 72nd minute when Evan Ndicka went to ground with chest pains and breathing difficulties, which later turned out to be due to a collapsed lung.
Obviously, he is unavailable along with suspended Bryan Cristante and ineligible Dean Huijsen, so Edoardo Bove steps into midfield and Chris Smalling in defence.
It was confirmed today that coach Daniele De Rossi will have his contract extended beyond the end of this season.
Milan played a 3-3 thriller away to Sassuolo at the weekend, losing Simon Kjaer to injury along with Pierre Kalulu and Tommaso Pobega.
Mike Maignan missed that match with a slight muscular issue, but returns here, while Fikayo Tomori is back after missing the first leg against Roma through suspension.
It is the usual first-choice attack with Rafael Leao, Ruben Loftus-Cheek and Christian Pulisic fanning out behind Giroud.
There had been suggestions Yunus Musah would be preferred to Ismael Bennacer, but instead it’s Tijjani Reijnders on the bench.
The away goals rule no longer exists, so any Milan win by a one-goal margin would prompt extra time.
Roma: Svilar; Celik, Mancini, Smalling, Spinazzola; Bove, Paredes, Pellegrini; El Shaarawy, Lukaku, Dybala
Roma bench: Rui Patricio, Boer, Karsdorp, Abraham, Diego Llorente, Azmoun, Renato Sanches, Aouar, Baldanzi, Zalewski, Joao Costa, Angelino
Milan: Maignan; Calabria, Gabbia, Tomori, Theo Hernandez; Bennacer, Musah; Pulisic, Loftus-Cheek, Leao; Giroud
Milan bench: Sportiello, Nava, Adli, Reijnders, Jovic, Okafor, Chukwueze, Thiaw, Terracciano, Florenzi, Zeroli, Bartesaghi
Ref: Marciniak (POL)
