Zlatan Ibrahimovic, Kevin-Prince Boateng, Robinho, Massimo Ambrosini and Gennaro Gattuso are out of Milan's trip to Napoli.
Coach Massimiliano Allegri released the list of 21 players travelling to the San Paolo for Sunday night's Serie A game.
Ibrahimovic is still sidelined with a thigh problem, while Robinho is yet to play this season due to a groin strain.
Boateng limped off during the 2-2 draw with Barcelona and there are reports he may have suffered a stress fracture to his rib.
Captain Ambrosini has been ruled out for a month after dislocating his shoulder.
Milan squad: Abbiati, Amelia, Roma, Abate, Antonini, Bonera, Nesta, Taiwo, Thiago Silva, Yepes, Aquilani, Emanuelson, Nocerino, Seedorf, Valoti, Van Bommel, Carmona, Cassano, El-Shaarawy, Ganz, Pato