Juventus and Milan could be the big winners when Week 16 comes to an end on Sunday evening.
The Old Lady of Italian football are top of the League alongside Udinese, two points clear of the Rossoneri and Lazio.
While Juve and Milan host Novara and Siena respectively, Lazio and Udinese meet in the capital in a tie that will see at least one team drop points.
Elsewhere, Inter are away at Cesena and Napoli entertain Roma in one of the biggest games of the weekend.
For individual match previews, please click here.
See the latest Serie A predictions and betting tips with Eurotips.co.uk