Roma hope to ride the wave of enthusiasm as they travel to Bologna with Francesco Totti, Erik Lamela and Pablo Daniel Osvaldo.
The Giallorossi are suddenly brimming with confidence after holding Juventus and conquering Napoli at the San Paolo.
The absentee list includes Fabio Borini, Simon Kjaer, Marco Cassetti and Nicolas Burdisso.
Luis Enrique changed his side again, bringing back Miralem Pjanic from suspension, while Aleandro Rosi and Rodrigo Taddei are the full-backs.
Bologna have lost the last two editions of this Serie A fixture without scoring a goal.
Veteran hitman Marco Di Vaio hopes to make a dent in the reshuffled Roma defence with Alessandro Diamanti.
Bologna:Gillet; Crespo, Raggi, Portanova, Morleo; Casarini, Perez, Kone; Ramirez, Diamanti; Di Vaio
Roma: Stekelenburg; Rosi, Juan, Heinze, Taddei; Pjanic, De Rossi, Simplicio; Totti; Lamela, Osvaldo
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