Fiorentina have switched to a 3-5-2 system with Adem Ljajic and Stevan Jovetic up front in their trip to Novara.
The Viola sold Alberto Gilardino to Genoa this week and are without Santiago Silva or Khouma Babacar, so prepared for this game without a single recognised striker.
Support forwards Jovetic and Ljajic are forced into an unusual pairing and Coach Delio Rossi has changed their entire tactical system with a three-man defence.
Novara give their new signing Andrea Caracciolo his debut in attack along with Riccardo Meggiorini and Andrea Mazzarani.
Fiorentina: Boruc; Gamberini, Natali, Nastasic; Cassani, Behrami, Montolivo, Salifu, Vargas; Jovetic, Ljajic
Fiorentina bench:>Neto, Cerci, De Silvestri, Camporese, Lazzari, Pasqual, Kharja, Romulo
Novara: Ujkani; Gemiti, Centurioni, Paci, Morganella; Rigoni, Porcari, Marianini; Mazzarani; Meggiorini, Caracciolo
Novara bench:Fontana, Pinardi, Jenzen, Rubino, Dellafiore, Granoche, Garcia
See the latest Serie A predictions and betting tips with Eurotips.co.uk