Philippe Mexes has not travelled to Switzerland where Roma face Basel in the Champions League tomorrow night.
The France international is suffering from the flu, which in turn brought about an asthma attack.
It's a blow to Claudio Ranieri's plans as Matteo Brighi was also ruled out for three weeks yesterday after he picked up a thigh strain.
Francesco Totti isn't 100 per cent fit either according to Roma's medical staff who are worried about a potential back problem.
See the latest Serie A predictions and betting tips with Eurotips.co.uk