It's Mirko Vucinic and Jeremy Menez against Amauri and Alex Del Piero in the Coppa Italia quarter-final, Juventus-Roma.
The Bianconeri are dealing with another injury crisis and have few alternatives, but Gigi Del Neri has still made some changes.
Felipe Melo returns to the midfield with Momo Sissoko, as his three-match Serie A ban does not apply to the Coppa Italia.
It means Alberto Aquilani does not get the opportunity to start against his hometown club.
Simone Pepe and Jorge Martinez take the wings with Amauri and Alessandro Del Piero in attack.
Gigi Buffon is rested in favour of Marco Storari between the posts.
Roma were expected to field Marco Borriello in attack, but instead Claudio Ranieri has chosen a more mobile front three.
Simone Perrotta acts as trequartista with Mirko Vucinic and Jeremy Menez in what could turn into a 4-3-3 system.
Francesco Totti continues to sit out his lengthy ban in the Coppa.
The winners of this tie will go on to face Inter in the Coppa Italia semi-final.
Juventus: Storari; Motta, Bonucci, Chiellini, Grygera; Martinez, Felipe Melo, Sissoko, Pepe; Amauri, Del Piero
Juventus bench: Manninger, Sorensen, Grosso, Aquilani, Krasic, Marchisio, Iaquinta
Roma: Julio Sergio; Cassetti, Mexes, N Burdisso, Riise; Simplicio, De Rossi, Brighi; Perrotta; Vucinic, Menez
Roma bench: Doni, Juan, Rosi, Castellini, Greco, Taddei, Borriello
See the latest Serie A predictions and betting tips with Eurotips.co.uk