Sampdoria need a victory to escape the relegation zone, but local rivals Genoa have no intention of making it easy for them.
The Blucerchiati slipped into the bottom three after this afternoon's results and must pick up points in the 19.45 UK time kick-off.
Fans aren't too hopeful, as many of the Samp tickets have not been sold for the Derby della Madonnina.
Gianluca Curci is not 100 per cent fit, so Junior Da Costa starts between the posts, while Jonathan Biabiany and Nicola Pozzi are the strikers.
It means both Massimo Maccarone and Federico Macheda are left on the bench to begin with.
Gilberto Martinez, Marco Padalino and Franco Semioli are out injured.
Genoa have a full squad at their disposal and nothing to play for but pride, so their only focus now is sending their arch-rivals into Serie B.
Omar Milanetto, Rodrigo Palacio and Marco Rossi all return from their bans, while Miguel Veloso is on the bench after six weeks on the treatment table.
Genoa: Eduardo; Mesto, Dainelli, Kaladze, Criscito; Rafinha, Milanetto, Kucka, Rossi; Palacio, Floro Flores
Sampdoria: Da Costa; Zauri, Volta, Lucchini, Ziegler; Laczko, Palombo, Tissone, Mannini; Biabiany, Pozzi
See the latest Serie A predictions and betting tips with Eurotips.co.uk