Cesare Prandelli plans big changes for Tuesday's friendly with the Republic of Ireland, including Alessandro Matri and Giampaolo Pazzini.
Italy impressed in their 3-0 victory over Estonia for Friday's Euro 2012 qualifier and are set to experiment in the final game of the season, which is on neutral turf in Belgium.
Alberto Aquilani has joined Mario Balotelli and Thiago Motta in pulling out due to injury, while Torino defender Angelo Ogbonna could get a run-out after his debut call.
According to Sunday's training session, it looks as if Prandelli will make sweeping changes to the side that started against Estonia.
Mattia Cassani, Alessandro Gamberini and Domenico Criscito should step into the back four, leaving only Giorgio Chiellini as a senior figure.
In midfield Sampdoria captain Angelo Palombo was used along with Claudio Marchisio and Antonio Nocerino, using Sebastian Giovinco in the trequartista role.
Pazzini came off the bench to score on Friday, but should start with Juventus striker Matri, although Alberto Gilardino is another option.
One man who won't be taking part is Davide Astori, as the Cagliari defender will be suspended due to a red card sustained in a friendly against Ukraine several months ago.