Marco Storari was the hero as Cagliari beat Trapani on penalties, but Frosinone crash out of the Coppa Italia.
Earlier today, Empoli joined Bologna in crashing out of the competition, as top flight sides fell to lower League opposition.
In the early evening fixture, Sassuolo emerged victorious from the local derby with Modena, and will now face Cagliari in the next round.
The Neroverdi opted not to start with new signing Gregoire Defrel, but Domenico Berardi was deployed from the first minute.
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