Lazio look to Capocannoniere Ciro Immobile and Joaquin Correa, while Juventus can recapture top spot with Paulo Dybala and Cristiano Ronaldo.
It kicks off at the Stadio Olimpico at 19.45 GMT.
This is a top of the table showdown between third and second, but as Inter were held to a goalless draw by Roma last night, a victory would make Juventus the new leaders.
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