Kvicha Kvaratskhelia recovers to start for Napoli with a completely reshuffled defence in the trip to unpredictable Empoli.
It kicks off at the Stadio Castellani at 17.00 UK time (16.00 GMT).
You can follow all the build-up and action as it happens from this game and Verona–Udinese on the LIVEBLOG.
The Partenopei need a victory to get back into the race for European qualification after their disappointing 2-2 home draw with Frosinone.
Both Amir Rrahmani and Mario Rui are suspended, with Mathias Olivera injured, but the good news is the return to fitness of Kvaratskhelia and Juan Jesus with Victor Osimhen.
Pasquale Mazzocchi was meant to start, but he was struck by a bout of flu, so Natan returns for his first appearance since February 28.
Empoli are hovering one point above the relegation zone and their recent form has been disastrous, losing five of the last six without scoring a single goal.
The only outlier was a 3-2 victory over Torino on April 6.
Tyronne Ebuehi, Ardian Ismajli and Etrit Berisha are the only remaining players on the treatment table, as Alberto Grassi has now recovered.
M’Baye Niang has four goals in his nine Serie A appearances since the January transfer from Adana Demirspor, but is again benched in favour of Alberto Cerri.
Empoli: Caprile; Bereszynski, Walukiewicz, Luperto; Gyasi, Maleh, Grassi, Pezzella; Fazzini, Cambiaghi; Cerri
Napoli: Meret; Di Lorenzo, Ostigard, Juan Jesus, Natan; Anguissa, Lobotka, Zielinski; Politano, Osimhen, Kvaratskhelia
