Italy are unbeaten at San Siro, but have drawn their last four here, while Milan joins Rome as the most popular Azzurri venue after hosting Portugal tonight.
The Nations League clash kicks off at the Stadio Giuseppe Meazza at 19.45 GMT.
It comes a year after the 0-0 draw with Sweden ruled Italy out of the 2018 World Cup, having lost the first leg of the play-off 1-0.
That was their fourth consecutive stalemate at San Siro after friendlies against Germany in both 2013 and 2016, plus a Euro 2014 qualifier with Croatia.
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