Inter can mathematically seal the Scudetto with Derby della Madonnina victory as Lautaro Martinez returns, but Milan revamp with Rafael Leao as centre-forward and Christian Pulisic on the left.
It kicks off at San Siro at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens from this game and Roma–Bologna on the LIVEBLOG.
The gap at the top of the table is 14 points, so if Inter win this evening, they will also be mathematically crowned the new Champions of Italy.
Naturally, Milan want to do everything to avoid getting the party started for their arch-rivals, especially as this is their ‘home’ fixture and therefore it is a majority of Rossoneri fans in the stadium.
Stefano Pioli takes radical steps after Thursday’s Europa League quarter-final defeat to 10-man Roma.
Malick Thiaw is suspended, with Simon Kjaer and Pierre Kalulu on the treatment table, so there are few choices to be made in defence.
However, the rest is transformed with Olivier Giroud dropped, Rafael Leao moved to a new centre-forward role and Pulisic shifted over to the left, making room for his USMNT teammate Yunus Musah on the right.
Inter welcome Lautaro Martinez and Benjamin Pavard back from suspension after they missed the 2-2 draw with Cagliari.
Juan Cuadrado is the only remaining absentee, so Marcus Thuram starts upfront with ex-Milan star Hakan Calhanoglu in midfield.
The only doubt was on the right wing, where Matteo Darmian is preferred to Denzel Dumfries.
In all competitions, Inter have won the last five meetings with Milan, conceding just one goal and scoring 12, including a 5-1 humiliation in September 2023.
Milan vs. Inter official line-ups
Milan: Maignan; Calabria, Gabbia, Tomori, Theo Hernandez; Adli, Reijnders; Musah, Loftus-Cheek, Pulisic; Leao
Inter: Sommer; Pavard, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Thuram
Player statistic
| 18' |  |
Francesco Acerbi (Assist: Benjamin Pavard) | ||
| 22' |  |
Nicolò Barella | ||
| 32' | |
Lautaro Martínez | ||
| Theo Hernández | |
36' |
| 49' | |
Marcus Thuram | ||
| Fikayo Tomori | |
80' | ||
| Matteo Gabbia | |
90' | ||
| Fikayo Tomori | |
90+2' | ||
| Theo Hernández |  |
90+3' | ||
| Davide Calabria | |
90+7' | ||
| 90+3' | |
Denzel Dumfries |
Match statistic
