Roma give Cengiz Under and Maxime Gonalons rare starts, partnering Edin Dzeko and Stephan El Shaarawy against SPAL.
It kicks off at 17.30 GMT, follow the build-up and action from this game and Napoli-Juventus on the LIVEBLOG.
Eusebio Di Francesco has to revitalise his squad after their surprise 1-1 draw with Genoa in Serie A and 2-0 Champions League defeat to Atletico Madrid.
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/