While Portugal lose Rony Lopes to injury, Italy reportedly transform to a 4-4-2 with Simone Zaza and Ciro Immobile together.
The UEFA Nations League match kicks off in Lisbon at 19.45 UK time (18.45 GMT).
Roberto Mancini has cut several players from the squad that drew 1-1 with Poland, removing Mario Balotelli, Cristiano Biraghi, Daniele Rugani, Davide Zappacosta, Lorenzo Pellegrini, Nicolò Zaniolo and Alessio Cragno.
Enable Scroll-To-Play Video
Do Not Exclude From Feeds
Watch Serie A live in the UK on Premier Sports for just £9.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://www.premiersports.com/subscribenow