Mateo Retegui and Albert Gudmundsson lead the way for Genoa against Taty Castellanos and Felipe Anderson, as Lazio try to get into Europe.
It kicks off at Marassi at 17.30 UK time (16.30 GMT).
You can follow all the build-up and action as it happens from this game and Cagliari–Juventus on the LIVEBLOG.
The Grifone are unbeaten in four, but three of those were stalemates to keep them comfortably mid-table.
Junior Messias, Ruslan Malinovskyi, Mattia Bani and Alan Matturro are injured, but Retegui returns to the starting XI with Gudmundsson moved into a deeper role to fill the gaps.
Lazio make the trip without Ciro Immobile, Mattia Zaccagni, Matteo Guendouzi and Ivan Provedel.
The club was shaken by news Luis Alberto requested a transfer and Felipe Anderson has already signed for Palmeiras from July 1 as a free agent.
Genoa: Martinez; Vogliacco, De Winter, Vasquez; Spence, Frendrup, Strootman, Gudmundsson, Martin; Ekuban, Retegui
Lazio: Mandas; Patric, Casale, Gila; Marusic, Vecino, Kamada, Lazzari; Felipe Anderson, Luis Alberto; Castellanos
