Juventus start Carlos Alcaraz, Federico Chiesa and Dusan Vlahovic in a trip to giant-killers Cagliari.
It kicks off at the Unipol Domus arena at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens from this game and Genoa–Lazio on the LIVEBLOG.
The Bianconeri continue to stutter following the 0-0 draw with Torino and have not yet secured a Champions League spot.
Moise Kean and Fabio Miretti have not made the trip to Sardinia, but Wojciech Szczesny does start in goal less than a week after fracturing his nose.
Arkadiusz Milik returns for a place on the bench, though Chiesa and Vlahovic are still trying to form a partnership.
The big change is in midfield, where Alcaraz gets his first start since March 3, sending Weston McKennie to the bench.
Cagliari are pushing to break away from the relegation zone and are currently four points clear after beating Atalanta and holding Inter to a 2-2 draw.
Nahitan Nandez and Alessandro Deiola return from suspension, while Gaetano Oristanio has recovered from a bout of tonsillitis.
Andrea Petagna, Leonardo Pavoletti and Marco Mancosu are still out of action, so Zito Luvumbo and Eldor Shomurodov lead the attack.
Cagliari: Scuffet; Mina, Dossena, Hatzidiakos; Nandez, Makoumbou, Sulemana, Augello; Gaetano, Luvumbo; Shomurodov
Juventus: Szczesny; Gatti, Bremer, Danilo; Weah, Alcaraz, Locatelli, Rabiot, Cambiaso; Vlahovic, Chiesa
