Suso is given a new supporting role behind Nikola Kalinic as Milan visit unbeaten Sampdoria and their hitman Duvan Zapata.
It kicks off at 11.30 UK time (10.30 GMT), follow the build-up and action from all seven Serie A games on the LIVEBLOG.
This is a homecoming for Vincenzo Montella, who wore the Blucerchiati colours both as a player and a Coach.
He returns to Marassi at the helm of Milan, who have won every competitive game this season except for the 4-1 defeat to Lazio.
There are injury concerns, as Andrea Conti, Luca Antonelli, Davide Calabria and Riccardo Montolivo all miss out.
Ignazio Abate is not at 100 per cent either, but he starts in a 3-5-1-1 formation with winger Suso in a more central role supporting Kalinic.
The Spaniard knows this stadium well, having impressed during a loan spell at Genoa.
Sampdoria have a game in hand, as their home clash with Roma was called off amid weather warnings, but they are still unbeaten this season with two wins and as many stalemates.
They were unlucky in the midweek round, pegged back by Hellas Verona with two goal-line clearances.
Emiliano Viviano and Dodo remain on the treatment table, so Christian Puggioni again takes the gloves.
Duvan Zapata is preferred to Gianluca Caprari as the partner for Fabio Quagliarella, backed by trequartista Gaston Ramirez.
This means Duvan Zapata will be marked by his cousin and fellow Colombia international Cristian Zapata.
Milan are unbeaten at Marassi since a 2-1 result in April 2010, emerging with five victories and two draws between Serie A and the Coppa Italia.
Sampdoria: Puggioni; Bereszynski, Silvestre, Ferrari, Strinic; Barreto, Torreira, Praet; Ramirez; Quagliarella, Duvan Zapata
Sampdoria bench: Tozzo, Andersen, Sala, Caprari, Djuricic, Alvarez, Linetty, Regini, Verre, Capezzi, Murru, Kownacki
Milan: G Donnarumma; C Zapata, Bonucci, Romagnoli; Abate, Kessie, Biglia, Bonaventura, Rodriguez; Suso; Kalinic
Milan bench: A Donnarumma, Storari, Musacchio, Paletta, Calhanoglu, Locatelli, Mauri, Borini, Cutrone, Andre Silva