Juventus have a tough task and look to Mirko Vucinic against his former club, as Serse Cosmi’s desperate Lecce come to Turin ready to cause an upset.
The Bianconeri are still unbeaten this season, setting an all-time Serie A record, and with a three-point lead at the top of the table are close to the Scudetto celebrations.
Simone Pepe is the only absentee, as Alessandro Matri returns from suspension, but only gets a place on the bench.
Instead Fabio Quagliarella is picked to partner ex-Lecce star Vucinic, who started his Serie A career with the Salentini.
Antonio Conte has opted for a three-man defence with Stephan Lichtsteiner and Paolo De Ceglie in more advanced roles.
Lecce are only one point adrift of the safety zone, but have slowed down their remarkable ascent recently and Cosmi hopes this atmosphere can shake up the squad.
He also welcomes back Juan Cuadrado from suspension, but Andrea Esposito is banned with Massimo Oddo, Daniele Corvia and Julio Sergio injured.
Udinese-owned Luis Muriel is surprisingly dropped after losing form recently, so 20-year-old ex-Fiorentina youngster Haris Seferovic starts with veteran David Di Michele.
Juventus: Buffon; Barzagli, Bonucci, Chiellini; Lichtsteiner, Vidal, Pirlo, Marchisio, De Ceglie; Quagliarella, Vucinic
Juventus bench: Storari, Caceres, Padoin, Giaccherini, Del Piero, Borriello, Matri
Lecce: Benassi; Tomovic, Carrozzieri, Miglionico; Cuadrado, Blasi, Obodo, Delvecchio, Brivio; Di Michele, Seferovic
Lecce bench: Petrachi, Di Matteo, Giandonato, Giacomazzi, Bertolacci, Muriel, Bojinov