Mattia Destro returned to Roma training on Wednesday, but Pablo Daniel Osvaldo failed to finish the session.
The summer signing from Siena, via Genoa, underwent an x-ray on Tuesday after picking up a foot problem in the 3-2 loss to Bologna.
Destro was subsequently cleared to resume training which he did earlier today, but there are now concerns over Osvaldo.
The Argentine-born Italian international twisted his left knee while striking the ball which has left him as a doubt for the weekend game at Cagliari.
The former Bologna man will be closely monitored over the next 24 hours.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.