Lazio were under pressure for long spells but emerged with a creditable goalless draw from their trip to Tottenham.
Andre Villas Boas picked a very strong Spurs line-up for the Europa League opener At White Hart Lane, giving new boys Clint Dempsey, Moussa Dembele and Hugo Lloris starts.
Vladmir Petkovic stuck with his 4-1-4-1, introducing Senad Lulic and Ogenyi Onazi.
Miroslav Klose failed to connect with a Lulic cross which flashed across the six yard line.
Federico Marchetti tipped a Gareth Bale header over the bar, then Dempsey netted a diving header from a sumptuous Bale cross, but it was deemed offside.
Stefano Mauri scampered onto a long ball and flicked a pass into Klose's path, but the German miskicked and the chance was wasted.
Alvaro Gonzalez was ever so close to giving Lazio the lead in the 41st minute, his wonderfully executed volley from the edge of the box crashing down off the crossbar!
There was a big chance for the home side five minutes after the break, Luis Cavanda eventually clearing after Dempsey and Aaron Lennon had both came close in a goalmouth scramble.
There was a large and very vocal travelling support, who taunted their hosts by chanting the name of Paolo Di Canio – who played for Lazio and Spurs London rivals West Ham.
Sandro's diving header from a wicked in-swinging Bale free kick flew narrowly wide.
Tottenham then had yet another goal ruled out, Steven Caulker's header from a corner chalked off because the defender was leaning on Mauri.
The last chance fell to Spurs sub Andros Townsend, whose downward header bounced off the turf and over the bar.
Tottenham 0 Lazio 0
Tottenham: Lloris; Walker, Vertonghen, Caulker, Naughton; Lennon (Townsend 81), Dempsey (Sigurdsson 76), Sandro, Dembele (Mason 94), Bale; Defoe
Lazio: Marchetti; Cavanda, Biava, Dias, Lulic; Onazi (Zarate 81), Ledesma, Hernanes (Ciani 94), Gonzalez; Mauri (Ederson 93); Klose
Ref: Hategan (ROM)