Lazio must beat Genoa to stay joint top of the table this evening, so look to Mauro Zarate and Libor Kozak.
The Biancocelesti are the only side who can join Juventus on a 100 per cent record and a fourth straight victory would also set a new club best ever start to the season.
Cristian Brocchi, Stefan Radu, Mobido Diakite, Abdoulay Konko and Ederson are unavailable, but Vladimir Petkovic opts for Zarate and Kozak in a 4-4-2 system.
It is a change from the 4-1-4-1 used until recently, as Miroslav Klose is rested. Michael Ciani gets his first Serie A start in defence, joined by Lionel Scaloni.
Genoa have impressed with their performances this season, but tended to drop leads in dramatic fashion.
Ciro Immobile and Marco Borriello continue to work on their new partnership in attack, but Marco Rossi and Juan Manuel Vargas are injured.
Surprisingly, Hungarian international Daniel Tozser is given the trequartista role behind the strikers rather than Cristobal Jorquera or Andrea Bertolacci.
Lazio: Marchetti; Scaloni, Biava, Ciani, Cavanda; Candreva, Ledesma, Hernanes, Lulic; Zarate, Kozak
Lazio bench: Bizzarri, Carrizo, Dias, Stankevicius, Zauri, Cana, Onazi, Mauri, Gonzalez, Rocchi, Klose, Floccari
Genoa: Frey; Sampirisi, Canini, Granqvist, Moretti; Kucka, Merkel, Anselmo; Tozser; Borriello, Immobile
Genoa bench: Tzorvas, Antonelli, Bovo, Ferronetti, Bertolacci, Jankovic, Stillo, Piscitella, Seymour, Jorquera, Melazzi