Lazio need to get back on track against giant-killers Siena, but have to do so without leading light Hernanes.
The Biancocelesti had their best start to a season since 1975, but have now lost two on the bounce, including Wednesday’s 3-0 drubbing at Napoli.
Hernanes failed a fitness test, so Ederson gets his first start in a Lazio jersey supporting Miroslav Klose.
Giuseppe Biava and Andre Dias return to being the centre-back partnership, but Stefan Radu and Cristian Brocchi are still unavailable.
Siena have earned a reputation as giant-killers in recent weeks, as Serse Cosmi’s men earned surprise victories over Inter and Bologna.
Alessandro Rosina and Matteo Contini do not make it for this trip, but Francesco Valiani is bumped up into the starting XI behind Emanuele Calaio.
Lazio: Marchetti; Konko, Biava, Dias, Lulic; Candreva, Gonzalez, Ledesma, Ederson, Mauri; Klose
Lazio bench: Bizzarri, Carrizo, Ciani, Cavanda, Scaloni, Cana, Hernanes, Onazi, Rocchi, Floccari, Zarate, Kozak
Siena: Pegolo; Neto, Paci, Felipe; Sestu, Vergassola, D’Agostino, Del Grosso; Valiani, Verre; Calaiò
Siena bench: Farelli, Dellafiore, Rodriguez, Rubin, Martinez, Ze Eduardo, Angelo, Bolzoni, Paolucci, Bogdani, Campos Toro, Reginaldo