Napoli need a result away to Group leaders Dnipro, but revolutionise their squad with Juan Zuniga, Lorenzo Insigne and Edu Vargas.
The Partenopei are in Ukraine for tonight’s Europa League match, which kicks off at 20.05 BST.
Zuniga is a last-minute introduction into the midfield, while Edinson Cavani is on the bench and Marek Hamsik suspended.
Omar El Kaddouri is dropped after his disastrous performance against PSV Eindhoven.
Dnipro have a 100 per cent record in Group F and are unbeaten in Europe this season, including the play-offs.
Dnipro: Lastuvka; Mazuch, Mandziuk, Strinic, Fedetskiy, Giuliano, Cheberyachko, Rotan, Zozulya, Seleznyov, Matheus
Dnipro bench: Shelikov, Denisov, Odibe, Kravchenko, Kankava, Aliyev, Kalinic
Napoli: Rosati; Aronica, Fernandez, Gamberini; Dossena, Donadel, Zuniga, Dzemaili, Mesto; Vargas, Insigne
Napoli bench: De Sanctis, Uvini, Cannavaro, El Kaddouri, Inler, Cavani, Pandev