Roma miss Daniele De Rossi and Leandro Castan, but welcome a Palermo side that has a similar all-attack approach to football. Bring on the fireworks!
The Giallorossi are losing faith in their Coach after two consecutive 3-2 defeats when they had been in front.
Maarten Stekelenburg and Bogdan Lobont are injured, while Daniele De Rossi, Pablo Daniel Osvaldo and Leandro Castan were carrying injuries over the last few days, but of the trio only the striker starts.
It means another spell on the bench for Mattia Destro, as Erik Lamela and Francesco Totti keep their spots.
Mauro Goicoechea gets his first Serie A start in goal and Federico Balzaretti returns from injury to face his former club, while Panagiotis Tachtsidis is back from suspension.
Palermo have a tendency to be involved in plenty of goals and fumbling leads too, as they threw away a 2-0 advantage to draw 2-2 with Milan.
Massimo Donati and Mauro Cetto joined Abel Hernandez on the treatment table.
Fabrizio Miccoli is supported by Franco Brienza, leaving Josip Ilicic on the bench along with Paulo Dybala.
Roma: Goicoechea; Piris, Marquinhos, Burdisso, Balzaretti; Bradley, Tachtsidis, Florenzi; Lamela, Osvaldo, Totti
Roma bench: Svedkauskas, Castan, Marquinho, Taddei, Pjanic, De Rossi, Lopez, Perrotta, Destro, Dodò, Romagnoli
Palermo: Ujkani; Munoz, Von Bergen, Garcia; Morganella, Arevalo Rios, Kurtic, Barreto, Pisano; Brienza, Miccoli
Palermo bench: Benussi, Mantovani, Viola, Dybala, Bertolo, Milanovic, Zahavi, Giorgi, Labrin, Budan, Brichetto, Ilicic