Roma and Inter go head-to-head for the second time in three days, this time for the Coppa Italia semi-final with Mattia Destro starting and a revamped Nerazzurri attack.
These sides met at the Olimpico in a 1-1 Serie A draw on Sunday evening, but the first leg of the Coppa tie kicks off tonight at 19.45 GMT.
Daniele De Rossi is still out of action, joined by the suspended Pablo Daniel Osvaldo, Miralem Pjanic, Rodrigo Taddei and Dodo.
Maarten Stekelenburg returns to the goal, perhaps for the final time as reports of talks with Fulham gain traction.
Destro starts up front with Francesco Totti and Erik Lamela.
Inter’s injury woes continue, as Antonio Cassano, Diego Milito, Philippe Coutinho, Dejan Stankovic, Luca Castellazzi and Walter Samuel are still sidelined.
Esteban Cambiasso was rested against Roma on Sunday, but is back in the starting XI along with teenage talent Marco Benassi.
Curiously, Marko Livaja and Tommaso Rocchi are both benched in favour of Fredy Guarin in a more advanced role behind lone striker Rodrigo Palacio.
Roma: 24 Stekelenburg; 23 Piris, 3 Marquinhos, 29 Burdisso, 42 Balzaretti; 4 Bradley, 77 Tachtsidis, 48 Florenzi; 8 Lamela, 22 Destro, 10 Totti
Roma bench: 13 Goicoechea, 1 Lobont, 5 Castan, 7 Marquinho, 19 Antei, 20 Perrotta, 21 Sammartino, 45 Ricci, 47 Lucca
Inter: 1 Handanovic; 23 Ranocchia, 26 Chivu, 40 Juan Jesus; 4 Zanetti, 19 Cambiasso, 20 Obi, 24 Benassi, 31 Pereira; 14 Guarin; 8 Palacio
Inter bench: 27 Belec, 77 Di Gennaro, 6 Silvestre, 11 Alvarez, 16 Mudingayi, 17 Mariga, 18 Rocchi, 21 Gargano, 42 Jonathan, 55 Nagatomo, 82 Bessa, 88 Livaja