Napoli have the chance to close the gap on leaders Juventus to just two points as they take on Sampdoria with Pablo Armero and Lorenzo Insigne.
Last night the Bianconeri lost 1-0 to Roma, giving Walter Mazzarri’s men a golden opportunity in the Scudetto race.
A confidence booster is needed after Thursday’s humiliating 3-0 home Europa League defeat to Viktoria Plzen.
Insigne missed that game suffering from flu symptoms, but he is back in the starting XI along with Valon Behrami.
Ex-Udinese midfielder Armero is given his full Napoli debut, while Giandomenico Mesto again pushes Christian Maggio to the bench.
Edinson Cavani hasn’t scored in four official appearances, which is an unusual drought for El Matador.
Sampdoria have seen a revival under Delio Rossi, although the Coach is in the stands today beginning a two-match touchline ban for making offensive gestures towards the Roma bench.
Eder returns from compassionate leave in Brazil, but Angelo Palombo is out injured.
History does not smile upon Samp, as they have lost their last four trips to the San Paolo without finding the net.
Napoli: De Sanctis; Campagnaro, Cannavaro, Britos; Mesto, Behrami, Inler, Hamsik, Armero; Insigne, Cavani
Sampdoria: Romero; Gastaldello, Rossini, Costa; De Silvestri, Obiang, Krsticic, Poli, Estigarribia; Sansone, Icardi