Pescara are already relegated, but they play for pride against Champions League chasing Milan.
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The Rossoneri broke four points clear in third place at the weekend after scraping a 1-0 victory over Torino in the final minutes.
Mario Balotelli got the decisive goal and he leads the attack again with Robinho and M’Baye Niang, but Kevin-Prince Boateng is suspended and Stephan El Shaarawy rested.
Riccardo Montolivo, Luca Antonini, Bojan Krkic and Daniele Bonera all miss out due to injury.
Pescara are already doomed to Serie B, but have pride to play for in front of their home fans.
Gaetano D’Agostino, Francesco Modesto, Vladimir Weiss, Juan Fernando Quintero, Gianluca Caprari and Ivan Pelizzoli are unavailable.
Pescara: Perin; Zauri, Cosic, Capuano, Balzano; Rizzo, Togni, Di Francesco, Cascione; Sculli, Sforzini
Milan: Abbiati; Abate, Zapata, Yepes, Constant; Flamini, Muntari, Nocerino; Niang, Balotelli, Robinho
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