Napoli use a completely revamped line-up against Siena, including Omar El Kaddouri and Emanuele Calaiò.
The San Paolo hosts the encounter at 14.00 UK time (13.00 GMT), click here for a match preview.
The Partenopei have already secured second place, so there is a party atmosphere for their final home game of the season.
It could also be an emotional occasion if Walter Mazzarri and Edinson Cavani make this their last salute for the Napoli fans.
Coach Mazzarri has opted to give background players the stage, such as Antonio Rosati, El Kaddouri, Giandomenico Mesto, Gianluca Grava, Rolando and ex-Siena striker Calaiò.
Siena are now mathematically in Serie B already thanks to this morning's results and visit without the suspended Alessandro Rosina, injured Nicola Pozzi and Simone Vergassola.
Napoli: Rosati; Grava, Cannavaro, Rolando; Mesto, Dzemaili, Inler, El Kaddouri, Armero; Calaiò, Cavani
Siena: Pegolo; Terzi, Terlizzi, Felipe, Vitiello, Bolzoni, Calello, Della Rocca, Grillo, Agra, Emeghara
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!