Milan look to Mario Balotelli, Stephan El Shaarawy and Kevin-Prince Boateng against PSV in the Champions League play-off.
The first leg ended 1-1 in Eindhoven and the decider kicks off at San Siro at 19.45 UK time (18.45 GMT).
Although the result was positive in Holland, the Rossoneri’s confidence took a hammering on Saturday with a 2-1 defeat to Serie A new boys Hellas Verona.
Mattia De Sciglio and Nigel De Jong are back in the side after recovering from injury, though Daniele Bonera, Jherson Vergara, Giampaolo Pazzini and Gabriel are still absent.
PSV Eindhoven need at least an away goal to have a chance of going through to the group phase of the Champions League.
They are without the injured Luciano Narsingh and Oscar Hiljemark, while Georginio Wijnaldum has shaken off a minor knock he picked up at the weekend in the 1-1 draw with Heracles.
Milan: Abbiati; Abate, Zapata, Mexes, De Sciglio; Montolivo, De Jong, Muntari; Boateng, Balotelli, El Shaarawy
Milan bench: Amelia, Silvestre, Nocerino, Poli, Emanuelson, Niang, Robinho
PSV: Zoet; Brenet, Bruma, Rekik, Willems; Wijnaldum, Schaars, Maher; Park Ji-Sung, Matavz, Depay
PSV bench: Tyton, Jorgensen, Arias, Hendrix, Toivonen, Locadia, Jozefzoon