Lazio seek revenge against Juventus for the Super Cup thrashing, as Carlos Tevez and Paul Pogba take on Hernanes and Miroslav Klose.
This Serie A game kicks off in Turin at 19.45 UK time, click here for a match preview.
The two sides met only two weeks ago for the Italian Super Cup, which saw Juve emerge 4-0 winners from the Stadio Olimpico.
That humiliation still weighs heavily on the Aquile and Coach Vladimir Petkovic noted this was the perfect opportunity to prove “the gap isn’t that big.”
Stefano Mauri is still suspended awaiting an appeal verdict on his six-month ban for being aware of a potential fix.
Lorik Cana, Mickael Ciani, Libor Kozak, Bruno Pereirinha and Vinicius are not 100 per cent fit, while Abdoulay Konko is unavailable.
Klose leads the attack with support from Antonio Candreva, Hernanes and summer signing Lucas Biglia. The German international has never managed to put a goal past the Bianconeri.
Juventus have had a blistering start to the campaign and particularly Tevez, who netted against both Lazio and Sampdoria.
He again starts up front with Mirko Vucinic, as Fernando Llorente is struggling to settle into his new Serie A environment.
Pogba steps in for the injured Claudio Marchisio in midfield.
Last season Federico Marchetti was heroic here to earn Lazio a 0-0 draw, but they haven’t won in Turin since 2002-03.
Juventus: Buffon; Barzagli, Bonucci, Chiellini; Lichtsteiner, Vidal, Pirlo, Pogba, Asamoah; Tevez, Vucinic
Lazio: Marchetti; Cavanda, Novaretti, Cana, Radu; Gonzalez, Biglia, Hernanes, Lulic; Candreva; Klose
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!