Lazio begin their Europa League campaign against Legia Warsaw in Rome with teenage starlet Keita Balde given his full debut.
The match kicks off at the Stadio Olimpico at 20.05 UK time (19.05 GMT).
With the Rome Derby on Sunday, Vladimir Petkovic rotates the squad to rest Miroslav Klose, Cristian Ledesma, Antonio Candreva and Senad Lulic.
Lorik Cana is again at centre-back, while Eddy Onazi partners Hernanes in midfield.
It’s a return to the 4-3-3 system with Ederson and teenage ex-Barcelona talent Keita fanning out around Sergio Floccari.
Legia Warsaw have Georgia international Vladimir Dvalisvili on the bench. He had scored a hat-trick in a recent 5-3 win over Korona, but picked up an injury during yesterday’s training session.
First choice goalkeeper Dusan Kuciak is also unavailable, making way for Wojciech Skaba.
They are top of the Polish League table with 15 points from seven games and entered the Europa League after losing the Champions League play-off to Steaua Bucharest last month on away goals.
Lazio: Marchetti; Cavanda, Ciani, Cana, Konko; Gonzalez, Onazi, Hernanes; Ederson, Floccari, Keita Balde
Lazio bench: Berisha, Novaretti, Ledesma, Candreva, Lulic, Klose, Crecco
Legia Warsaw: Skaba; Broz, Rzeźniczak, Dossa Junior, Brzyski; Vrdoljak, Furman; Ojamaa, Radović, Kosecki; Saganowski
Legia bench: Wienczatek, Jodłowiec, Lukasik, Helio Pinto, Kucharczyk, Żyro, Dvalishvili