Sassuolo are still waiting for their first ever Serie A point and hope to get it against Inter in the early kick-off.
The Mapei Stadium in Reggio Emilia hosts this tie at 11.30am UK time (10.30 GMT), click here for a match preview.
Inter are flying high and their 100 per cent record was only ended by Juventus in a 1-1 draw last week.
Javier Zanetti and Cristian Chivu are the only significant injury absentees, while Diego Milito is on the bench after snapping knee ligaments in February.
Rodrigo Palacio is again supported by Ricky Alvarez with Saphir Taider in midfield instead of Mateo Kovacic.
Sassuolo have been able to score only one goal this season and conceded eight, despite numerous opportunities.
Ezequiel Schelotto faces his parent club. The winger was dropped like a stone by Walter Mazzarri, even left behind for the team’s pre-season US tour.
Antonio Floro Flores leads the attack, but goalkeeper Gianluca Pegolo only fit for the bench.
Francesco Acerbi starts in defence for his second appearance of the campaign, a welcome presence considering he needed emergency surgery to remove a testicular tumour over the summer.
This week Emanuele Terranova was ruled out for six months by a knee injury, while Carl Valeri, Luca Marrone, Gomes and the suspended Domenico Berardi are also unavailable.
Sassuolo: Pomini; Gazzola, Rossini, Acerbi, Ziegler; Kurtic, Magnanelli, Chibsah; Schelotto, Floro Flores, Missiroli
Inter: Handanovic; Campagnaro, Ranocchia, Juan Jesus; Jonathan, Guarin, Cambiasso, Taider, Nagatomo; Alvarez; Palacio