Napoli look good to continue their perfect record against a Sassuolo side who lost 7-0 at the weekend.
It kicks off at the Stadio San Paolo at 19.45 UK time (18.45 GMT), click here for a match preview.
Rafa Benitez’s men are on fire at the moment with a 100 per cent record in all competition and fresh from Sunday’s 2-1 victory away to Milan.
On the other hand, Sassuolo suffered a shock 7-0 home defeat to Inter at the weekend and are still without a single point.
Christian Maggio is out for a month following knee surgery, but Benitez rotates his squad to rest Lorenzo Insigne, Valon Behrami, Jose Maria Callejon, Raul Albiol and Miguel Angel Britos.
Sassuolo are without Carl Valeri, Luca Marrone, Emanuele Terranova and Gomes, but Gianluca Pegolo returns in goal.
More importantly, Domenico Berardi is finally available after the end of his lengthy ban to partner Simone Zaza and Ezequiel Schelotto in the 4-3-3 formation.
Napoli: Reina, Mesto, Cannavaro, Fernandez, Armero, Inler, Dzemaili, Pandev, Hamsik, Mertens, Higuain
Napoli bench: Rafael, Colombo, Britos, Uvini, Albiol, Bariti, Behrami, Callejon, Dadosevic, Insigne, Zapata
Sassuolo: Pegolo; Antei, Acerbi, Bianco, Longhi; Kurtic, Magnanelli, Laribi; Schelotto, Zaza, Berardi
Sassuolo bench: Pomini, Rosati, Pucino, Marzorati, Rossini, Ziegler, Missiroli, Chibsah, Alexe, Farias, Floro Flores, Masucci
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more