The pressure is on both Milan and Sampdoria to end their negative streaks, as Robinho again leads the way.
It kicks off at San Siro at 19.45 UK time (18.45 GMT), click here for a match preview.
Max Allegri’s job is once again thought to be in the balance after scraping just five points from as many Serie A games, as on Wednesday night Milan fought back to earn a stoppage-time 3-3 draw in Bologna.
Mario Balotelli continues his three-match ban for insulting the referee, while Kaka, Stephan El Shaarawy, Riccardo Montolivo, Mattia De Sciglio, Daniele Bonera, Giampaolo Pazzini, Matias Silvestre and Riccardo Saponara are injured.
Robinho, Alessandro Matri and Valter Birsa are again chosen in attack, while Cristian Zaccardo and Kevin Constant give Ignazio Abate and Urby Emanuelson a rest.
Sampdoria are still without a win this season and Delio Rossi is hanging by a thread, as there are already reports Gigi De Canio is prepared to take over.
Eder is still out injured with Antonino Barillà suspended following his red card in Wednesday’s 2-0 home defeat to Roma.
Milan-owned striker Andrea Petagna is on the bench for the Blucerchiati.
Milan’s Curva Sud is closed as punishment for anti-Neapolitan chants, though the ultras will gather outside the stadium before kick-off to protest the decision.
Milan: Abbiati; Zaccardo, Zapata, Mexes, Constant; Poli, De Jong, Muntari; Birsa, Robinho; Matri
Sampdoria: Da Costa; De Silvestri, Mustafi, Regini, Costa; Gavazzi, Obiang, Palombo, Wszolek; Sansone, Gabbiadini
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