Sassuolo will be hoping to cause another upset after holding Napoli, as they host an injury-hit Lazio.
It kicks off at the Mapei Stadium at 14.00 UK time (13.00 GMT), click here for a match preview.
The Neroverdi are fired up after earning the first Serie A point in their history, holding Napoli to a 1-1 draw at the San Paolo on Wednesday.
However, Coach Eusebio Di Francesco has a long list of injuries to contend with, ruling out Luca Antei, Carl Valeri, Luca Marrone, Emanuele Terranova, Gomes and Gazzola.
He still adopts an attacking approach with Simone Zaza and Domenico Berardi.
Lazio weren’t in much better shape, as they were without Miroslav Klose, Stefan Radu, Abdoulay Konko, Diego Novaretti, Giuseppe Biava and Stefano Mauri.
Antonio Candreva, Ederson and Hernanes support Sergio Floccari.
Sassuolo: Pegolo; Schelotto, Marzorati, Bianco, Acerbi, Ziegler; Kurtic, Magnanelli, Missiroli; Berardi, Zaza
Lazio: Marchetti; Cavanda, Ciani, Dias, Pereirinha; Hernanes, Ederson, Ledesma, Onazi, Candreva; Floccari