Napoli try to put their Arsenal woes behind them, but have to make changes against a sprightly Livorno side.
It kicks off at the Stadio San Paolo at 14.00 UK time (13.00 GMT), click here for a match preview.
Rafa Benitez lost his unbeaten record on the Partenopei’s bench with a 2-0 Champions League defeat to Arsenal on Tuesday.
That poor performance knocked confidence and also added to the injury list, which now includes Gonzalo Higuain, Raul Albiol, Juan Camilo Zuniga and Christian Maggio.
Therefore Dries Mertens and Federico Fernandez receive rare starts, as Benitez tinkers with his formation yet again.
Livorno may be newly promoted after winning the Serie B play-offs, but they have had a very bright start to the season.
Their four-round unbeaten streak was only ended by an extremely controversial penalty to lose 2-1 at Verona last week.
Marco Biagianti joins Ruben Botta on the sidelines, while Innocent Emeghara is the partner for Brazilian Paulinho.
Inter loaners Alfred Duncan, Ibrahima Mbaye and Francesco Bardi start along with ex-Napoli defender Leandro Rinaudo.
Livorno haven’t conquered Naples in over 70 years, last tasting victory in December 1940.
Napoli: Reina; Mesto, Fernandez, Britos, Armero; Behrami, Inler; Mertens, Hamsik, Callejon; Pandev
Livorno: Bardi; Coda, Rinaudo, Ceccherini; Schiattarella, Luci, Mbaye, Duncan, Greco; Paulinho, Emeghara