Antonio Cassano returns to face Inter at San Siro and hopes Parma can take another prestigious scalp.
It kicks off at 19.45 GMT to conclude Serie A Week 15, click here for a match preview.
All eyes will be on Cassano, who left the Nerazzurri over the summer in bitter circumstances and accused Coach Walter Mazzarri of not giving him a chance.
FantAntonio starts with the aid of a protective mask after undergoing surgery for a fractured nose this week.
Fellow ex-Interisti Jonathan Biabiany and Walter Gargano also start with 22-year-old former Bayern Munich youth product Nicola Sansone, though Joel Obi, Stefano Okaka, Nicola Pavarini and Daniele Galloppa are out injured.
Parma are on a strong run of results, including a shock away victory to Napoli, so will be eager to cause another upset.
Their history at San Siro is deeply disappointing, as the 3-1 win here in 1999 is the only bright light amid six draws and 15 defeats. They have lost each of their last seven visits to Inter.
The Nerazzurri have been stuttering lately, held to two consecutive League stalemates and winning just three of their last nine games.
On Wednesday they scraped a 3-2 Coppa Italia victory over Serie B minnows Trapani and must do without Mauro Icardi, Diego Milito, Walter Samuel and Cristian Chivu, while Yuto Nagatomo is only fit for the bench.
Mateo Kovacic is given a rare midfield start, Jonathan faces his old club and Andrea Ranocchia retains his spot in the back three. Javier Zanetti is well and truly back as a regular.
Inter: Handanovic; Campagnaro, Ranocchia, Juan Jesus; Jonathan, Kovacic, Cambiasso, Alvarez; Zanetti; Guarin; Palacio
Inter bench: Castellazzi, Garrizo, Andreolli, Belfodil, Mudingayi, Wallace, Taider, Puscas, Pereira, Rolando, Nagatomo, Olsen
Parma: Mirante; Cassani, Paletta, Lucarelli, Gobbi; Gargano, Marchionni, Parolo; Biabiany, Cassano, Sansone
Parma bench: Bajza, Coric, Mesbah, Valdes, Amauri, Palladino, Felipe, Mendes, Munari, Benalouane, Rosi