It’s the moment of truth as the top two teams go head-to-head in Turin with Andrea Pirlo and Carlos Tevez against Francesco Totti, Adem Ljajic and Gervinho.
It kicks off at 19.45 GMT, click here for a match preview.
Only five points separate these sides at the top of the table and this could be the decisive moment in the Scudetto race.
Juventus have won their last nine Serie A games in a row and lost only once all season, a spectacular 4-2 capitulation at Fiorentina.
Pirlo returns from a month out with a sprained knee to start in midfield with Arturo Vidal and Paul Pogba, while Andrea Barzagli also shook off a knock.
Tevez leads the attack with Fernando Llorente, aiming to end Roma’s unbeaten record this season.
Federico Balzaretti is the only absentee for Rudi Garcia’s men, who have Totti, Gervinho and Adem Ljajic all lining up together in attack.
Kevin Strootman and Daniele De Rossi return from suspension to complete the midfield with Miralem Pjanic.
Dodo takes the left-back slot with Douglas Maicon down the right.
The Giallorossi have a traditionally poor record in Turin, losing their last two visits 4-0 and 4-1.
Their most recent victory was in 2009-10, one of only eight Serie A wins here in 79 attempts.
It’s a special occasion at the Juventus Stadium, as Bianconeri legend David Trezeguet will salute the fans and receive an award from President Andrea Agnelli.
Juventus: Buffon; Barzagli, Bonucci, Chiellini; Lichtsteiner, Vidal, Pirlo, Pogba, Asamoah; Tevez, Llorente
Juventus bench: Storari, Rubinho, Isla, Caceres, Ogbonna, Peluso, De Ceglie, Padoin, Marchisio, Giovinco, Quagliarella, Vucinic
Roma: De Sanctis; Maicon, Benatia, Castan, Dodò; Pjanic, De Rossi, Strootman; Ljajic, Totti, Gervinho
Roma bench: Lobont, Skorupski, Burdisso, Romagnoli, Jedvaj, Torosidis, Taddei, Ricci, Bradley, Marquinho, Florenzi, Borriello, Caprari, Destro