Napoli host Atalanta in their bid to reach the Coppa Italia quarter-finals and David Moyes is reportedly in the stands.
It kicks off at the Stadio San Paolo at 20.00 GMT and the winners will face Lazio in the next phase on January 29.
Rafa Benitez gives an opportunity to start for players such as Duvan Zapata, Anthony Reveillere and Josip Radosevic.
However, Marek Hamsik is still only on the bench after strong reports he would be in the starting XI, what would be his first appearance since November 23.
Instead, Lorenzo Insigne, Goran Pandev and Jose Maria Callejon support Zapata.
Christian Maggio and Raul Albiol are also not given their rest.
Atalanta ended their six-round winless streak in Serie A at the weekend by beating Catania, but they have left behind Cristian Raimondi, Michele Canini and ex-Napoli striker German Denis.
Inter-owned Marko Livaja is the livewire in attack for Stefano Colantuono’s men.
Andrea Consigli is still unavailable after the goalkeeper came down with chicken pox.
Manchester United manager Moyes is said to be at the San Paolo, though it's not clear who he is scouting. He was spotted attending Cagliari-Juventus on Sunday afternoon.
Napoli: Rafael; Maggio, Albiol, Britos, Reveillere; Inler, Radosevic; Insigne, Pandev, Callejon; Zapata
Atalanta: Polito; Nica, Yepes, Benalouane, Del Grosso; Giorgi, Baselli, Cazzola, Kone; De Luca, Livaja