Inter desperately need a victory with President Erick Thohir in the stands and host bottom of the table Catania.
It kicks off at San Siro at 14.00 GMT, click here for a match preview.
Walter Mazzarri is feeling the pressure after losing three of the last five Serie A games and going out of the Coppa Italia to Udinese.
This week was dominated by controversy over Fredy Guarin’s abandoned exchange with Juventus striker Mirko Vucinic, so the Colombian is not in the squad.
Cristian Chivu is a long-term absentee, while Ishak Belfodil is out awaiting his loan move to QPR.
Rodrigo Palacio, Diego Milito and Ricky Alvarez start together in a 3-4-2-1 system.
Catania have had a tempestuous season, sacking Rolando Maran to bring in Gigi De Canio, then returning the original tactician to his post.
He made his ‘debut’ in last week’s 3-0 defeat to Fiorentina, so will be hoping for better this time round.
Francesco Lodi is a major boost, returning to midfield after his ban, though Pablo Barrientos is now suspended and Pablo Alvarez sidelined.
Fabian Rinaudo is given his Catania debut in midfield as they switch to a 3-5-1-1 tactic.
The Elefantini have never won at San Siro against Inter, but a draw here would be treated as a triumph.
Inter: Handanovic; Campagnaro, Rolando, Juan Jesus; Jonathan, Kuzmanovic, Cambiasso, Nagatomo; Alvarez, Palacio; Milito
Inter bench: Castellazzi, Carrizo, Zanetti, Andreolli, Icardi, Kovacic, Botta, Taider, Ranocchia, Samuel
Catania: Frison; Bellusci, Legrottaglie, Rolin; Peruzzi, Izco, Rinaudo, Lodi, Biraghi; Leto, Bergessio
Catania bench: Andujar, Ficara, Almiron, Plasil, Lopez, Guarente, Castro, Boateng, Gyomber, Keko, Capuano