Clarence Seedorf has the chance to make history with Milan, but Mario Balotelli is out against Alessio Cerci’s Torino.
It kicks off at 19.45 GMT, click here for a match preview.
Although they went out of the Coppa Italia to Udinese, the Rossoneri have the opportunity to win a third consecutive Serie A game.
No tactician has won his first three top flight fixtures on the Milan bench since Luigi Bonizzoni in 1958-59, so Seedorf could make history tonight.
It will be far from an easy task, as Balotelli sits out a ban with Stephan El Shaarawy, Cristian Zapata, Andrea Poli and Matias Silvestre injured.
Last week Giampaolo Pazzini scored his first Serie A goal in nine months to secure a last-gasp 2-1 victory in Cagliari, so he starts with support from Robinho, Keisuke Honda and Kaka.
New signing Adel Taarabt is on the bench after arriving on loan from QPR, joined by Michael Essien. Christian Abbiati returns in goal after suffering from flu.
Torino have a terrible record at San Siro, losing their last five consecutive visits here. However, they are on fine form and go into this weekend sixth in Serie A.
Cerci partners Ciro Immobile in an exciting front two, though Marcelo Larrondo and Alessandro Gazzi are injured.
Milan: Abbiati; De Sciglio, Bonera, Rami, Emanuelson; Muntari, Montolivo; Honda, Kaka, Robinho; Pazzini
Torino: Padelli; Maksimovic, Glik, Moretti; Darmian, Basha, Vives, Farnerud, Masiello; Immobile, Cerci